D-Amino Acid Oxidase Inhibitor

An inhibitor of DAAO (IC50s = 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively), selective for DAAO over a panel of 150 enzymes, receptors and ion channels (30 µM), inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner (10-200 mg/kg, i.p.), increases levels of D-serine in rat plasma and CSF, reduces formalin-induced paw flinching in rats (EC50 = 0.17 µg per animal). Formulation: A crystalline solid. InChI: InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10). InChIKey: PMHDSACGRKBACK-UHFFFAOYSA-N. SMILES: OC(C1=CC(SC=C2)=C2N1)=O