CYM-5478

Description: CYM-5478 is a potent and selective S1P2 agonist that significantly increases the viability of C6 cells in a dose-dependent manner at concentrations above 100 nM under nutrient-deprivation stress (produced by serum-starvation). Target: Others. Smiles: C(N1C(C)=C(C(CN2C=C(C(F)(F)F)C=CC2=O)=O)C=C1C)C3=CC=CC=C3. References: Deron R. Herr, Marie J. Y. Reolo, Yee Xin Peh, Wei Wang, Chang-Wook Lee, Rich Rivera, Ian C. Paterson & Jerold Chun. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Scientific Reports 6, Article number: 24541 (2016) doi:10.1038/srep24541.