Cyclouridine

Cyclouridine is an inhibitor of uridine phosphorylase (apparent Ki = 2.268 µM). It is selective for uridine phosphorylase over thymidine phosphorylase at 3.33 mM. Cyclouridine has also been used as a building block in the synthesis of compounds with anticancer or antiviral activities.Formal Name: 2R,3R,3aS,9aR-tetrahydro-3-hydroxy-2-(hydroxymethyl)-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one. CAS Number: 3736-77-4. Synonyms: 2,2'-Anhydrouridine, NSC 157148. Molecular Formula: C9H10N2O5. Formula Weight: 226.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 2 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@H]1[C@@]2([H])[C@](O[C@@H]1CO)([H])N3C(O2)=NC(C=C3)=O. InChi Code: InChI=1S/C9H10N2O5/c12-3-4-6(14)7-8(15-4)11-2-1-5(13)10-9(11)16-7/h1-2,4,6-8,12,14H,3H2/t4-,6-,7+,8-/m1/s1. InChi Key: UUGITDASWNOAGG-CCXZUQQUSA-N.