Cyclophosphamide-d4

Cyclophosphamide-d4 is intended for use as an internal standard for the quantification of cyclophosphamide (Cay-13849) by GC- or LC-MS. Cyclophosphamide is a nitrogen mustard alkylating agent. It acts as a prodrug and is converted to the active metabolite phosphoramide mustard (Cay-34078) via 4-hydroxycyclophosphamide and aldophosphamide intermediates by cytochrome P450s (CYP450s) in the liver. Cyclophosphamide (50 mg/kg) induces the formation of DNA interstrand crosslinks in leukemia cells isolated from an L1210 leukemia mouse model. It decreases the percentage of isolated peripheral blood lymphocytes expressing CD3, CD4, or CD19 when administered to mice at doses of 100 or 150 mg/kg. Cyclophosphamide (200 mg/kg) induces nephrotoxicity and hepatotoxicity in rats. It is teratogenic to embryos when administered to pregnant dams on day 11 of gestation at doses of 5, 10, or 20 mg/kg. Formulations containing cyclophosphamide have been used in the treatment of cancer and autoimmune disorders.Formal Name: N,N-bis(2-chloroethyl)tetrahydro-4,5-d2-2H-1,3,2-oxazaphosphorin-4,5-d2-2-amine 2-oxide. CAS Number: 173547-45-0. Molecular Formula: C7H11Cl2D4N2O2P. Formula Weight: 265.1. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: [H]N1P(OCC([2H])([2H])C1([2H])[2H])(N(CCCl)CCCl)=O. InChi Code: InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)/i1D2,4D2. InChi Key: CMSMOCZEIVJLDB-RUKOHJPDSA-N.