Cyclo(L-Leu-L-Pro)

Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 µg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 µg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.Formal Name: (3S,8aS)-hexahydro-3-(2-methylpropyl)-pyrrolo[1,2-a]pyrazine-1,4-dione. CAS Number: 2873-36-1. Synonyms: Maculosin 6. Molecular Formula: C11H18N2O2. Formula Weight: 210.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: 50 mg/ml. SMILES: O=C([C@H](CC(C)C)N1)N2[C@](CCC2)([H])C1=O. InChi Code: InChI=1S/C11H18N2O2/c1-7(2)6-8-11(15)13-5-3-4-9(13)10(14)12-8/h7-9H,3-6H2,1-2H3,(H,12,14)/t8-,9-/m0/s1. InChi Key: SZJNCZMRZAUNQT-IUCAKERBSA-N.