Cyclizine (hydrochloride)

Cyclizine is a histamine H1 receptor antagonist. It binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively). Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments with an IC50 value of 5.42 µM but induces histamine release with a 50% release concentration (RC50) of 10.81 µM. It reduces LPS-induced nitrite accumulation and protein levels of induced nitric oxide synthase (iNOS) in RAW 264.7 cells when used at a concentration of 100 nM. Cyclizine (10 and 20 mg/kg) reduces immobility in the forced swim test in rats.Formal Name: 1-(diphenylmethyl)-4-methyl-piperazine, monohydrochloride. CAS Number: 303-25-3. Molecular Formula: C18H22N2 . HCl. Formula Weight: 302.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: 1 mg/ml. SMILES: CN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1.Cl. InChi Code: InChI=1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17,/h2-11,18H,12-15H2,1H3,1H. InChi Key: UKPBEPCQTDRZSE-UHFFFAOYSA-N.