Curcumin-d6

Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin (Cay-81025, Cay-81025.1) by GC- or LC-MS. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities. It inhibits nitric oxide (NO) production (IC50 = 6 µM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin inhibits release of histamine and the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8 from HMC-1 mast cells. In vivo, curcumin decreases serum levels of histamine and TNF-alpha, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 µmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in mouse skin. Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.Formal Name: (1E,4Z,6E)-5-hydroxy-1,7-bis[4-hydroxy-3-(methoxy-d3)phenyl]-1,4,6-heptatrien-3-one. CAS Number: 1335198-02-1. Molecular Formula: C21H14D6O6. Formula Weight: 374.4. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: 0.1 M NaOH: >3 mg/ml, Acetone: >20 mg/ml. SMILES: OC(/C=C/C1=CC(OC([2H])([2H])[2H])=C(O)C=C1)=C\C(/C=C/C2=CC(OC([2H])([2H])[2H])=C(O)C=C2)=O. InChi Code: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,22,24-25H,1-2H3/b7-3+,8-4+,16-13-/i1D3,2D3. InChi Key: ZIUSSTSXXLLKKK-JGJCSXQMSA-N.