Cucurbitacin D

Cucurbitacin D is a triterpenoid that has been found in Cucurbita texana and has diverse biological activities. It decreases levels of the heat shock protein 90 (Hsp90) client proteins HER2, Raf, and cyclin-dependent kinase 6 (Cdk6) in MCF-7 breast cancer cell lysates in a concentration-dependent manner and inhibits the proliferation of MCF-7 cells (IC50 = 0.598 µM). Cucurbitacin D (0.1 µM) inhibits cigarette smoke condensate-induced HIV-1 replication in chronically HIV-1-infected U1 macrophages. In vivo, cucurbitacin D (0.025 mg/kg) decreases cold and mechanical allodynia in a mouse model of neuropathic pain induced by paclitaxel (Cay-10461).Formal Name: (2beta,9beta,10alpha,16alpha,23E)-2,16,20,25-tetrahydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione. CAS Number: 3877-86-9. Synonyms: (+)-Cucurbitacin D, Elatericin A, NSC 308606, NSC 521776. Molecular Formula: C30H44O7. Formula Weight: 516.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C1(C)C)[C@@H](O)C[C@]2([H])C1=CC[C@]([C@@](C[C@@H](O)[C@]3([H])[C@](O)(C)C(/C=C/C(C)(O)C)=O)(C)[C@]3(C)C4)([H])[C@@]2(C)C4=O. InChi Code: InChI=1S/C30H44O7/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6/h9,11-12,17-20,23,31-32,36-37H,10,13-15H2,1-8H3/b12-11+/t17-,18+,19-,20+,23+,27+,28-,29+,30+/m1/s1. InChi Key: SRPHMISUTWFFKJ-QJNWWGCFSA-N. Origin: Plant/Hemsleya amabilis.