Cu-GTSM

Cu-GTSM is a copper-containing compound and an analog of Cu-ATSM (Cay-17122) that has diverse biological activities. It is active against methicillin-sensitive and -resistant S. aureus clinical isolates (IC50s = 0.3-0.6 µM for all). Cu-GTSM inhibits the growth of SK-N-MC neuroepithelioma cells and MRC-5 fibroblasts (IC50s = 0.009 and 0.27 µM, respectively). It induces the production of reactive oxygen species (ROS) in SK-N-MC cells when used at a concentration of 5 µM. Cu-GTSM (2.5 mg/kg) reduces tumor burden in the transgenic adenocarcinoma of mouse prostate (TRAMP) model but induces weight loss and renal toxicity in the same model. Cu-GTSM-containing positron-emitting copper isotopes have been used in PET imaging applications for copper trafficking in the TASTPM transgenic mouse model of Alzheimer's disease.Formal Name: (SP-4-2)-[[2,2'-(1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato-kappaN2,kappaS]](2-)]-copper. CAS Number: 68341-14-0. Synonyms: CuII(gtsm), copper-GTSM. Molecular Formula: C6H10CuN6S2. Formula Weight: 293.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/mL, DMSO: 10 mg/mL, Ethanol: Slightly soluble, PBS (pH 7.2): 0.16 mg/mL. lambdamax: 316, 495 nm. SMILES: CNC1=N[N]2=CC=[N]3[Cu+2]2([S-]1)[S-]C(NC)=N3. InChi Code: InChI=1S/C6H12N6S2.Cu/c1-7-5(13)11-9-3-4-10-12-6(14)8-2,/h3-4H,1-2H3,(H2,7,11,13)(H2,8,12,14),/q,+2/p-2/b9-3+,10-4+,. InChi Key: ILQDIMXONQDSFP-RUACYTINSA-L.