CSF1R-IN-26

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T206224-10mg	10 mg	-	-	-	5 - 10 business days*		-
TGM-T206224-50mg	50 mg	-	-	-	5 - 10 business days*		-

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Description: CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It... more

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Product information "CSF1R-IN-26"

Description: CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%. Target: STAT, c-Fms, Apoptosis, Akt, ERK