Cryogenine

Description: Cryogenine is an alkaloid originally isolated from H. salicifolia that exhibits anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50 = 424 µM) and, at a dosage of 100 mg/kg per day (p.o.), reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis. Target: Others. Smiles: [H][C@]12C[C@@]3([H])CCCCN3[C@@]([H])(C1)c1cc(OC)c(OC)cc1-c1cc(ccc1O)\C=C/C(=O)O2 , c:34, . References: Lema, W.J., Blankenship, J.W., and Malone, M.H. Prostaglandin synthetase inhibition by alkaloids of Heimia salicifolia. J. Ethnopharmacol. 15(2), 161-167 (1986).