Crizotinib

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
CDX-C0699-M010	10 mg		-	-	3 - 9 business days*		122.00€
CDX-C0699-M050	50 mg		-	-	3 - 9 business days*		367.00€

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White to off-white powder. Soluble in choroform, DMSO or methanol. Chemical. CAS: 877399-52-5.... more

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Product information "Crizotinib"

White to off-white powder. Soluble in choroform, DMSO or methanol. Chemical. CAS: 877399-52-5. Formula: C21H22Cl2FN5O. MW: 450.34. Synthetic. Crizotinib is an anticancer drug. It is a potent, orally bioavailable, ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor receptor), anaplastic lymphoma kinase (ALK) and ROS1 (c-ros oncogene 1). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models, inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable. Crizotinib was approved for treatment of a subtype of nonsmall-cell lung cancer (NSCLC) with ALK fusion mutations.

Keywords:	(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, PF 2341066, PF-02341066, PF02341066, Xalkori
Supplier:	Chemodex
Supplier-Nr:	C0699

Properties

MW:	450,34 D
Formula:	C21H22Cl2FN5O
Purity:	>98% (HPLC)
Format:	Solid

Database Information

CAS :

877399-52-5| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+20°C (International: +20°C)
Signal Word:	Warning
GHS Hazard Pictograms:
H Phrases:	H317, H319, H341, H400
P Phrases:	P273, P280, P305+P351+P338