Coumaphos

Coumaphos is an organophosphate pesticide. It is converted into the corresponding oxon metabolite in vivo, similar to other organophosphate pesticides, that inhibits acetylcholinesterase (AChE). It is active against adult, but not arrested stage, O. ostertagi helminths. Coumaphos is toxic to A. stephensi and A. aegypti mosquitoes when applied topically, with median lethal doses of 0.002 and 0.012 µg per female mosquito, respectively, but not when used as a contact insecticide. It is lethal to rats (LD50s = 41 and 16 mg/kg for male and female rats, respectively). Formulations containing coumaphos have been used to control pests in livestock.Formal Name: O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl), phosphorothioic acid, O,O-diethyl ester. CAS Number: 56-72-4. Synonyms: NSC 8944. Molecular Formula: C14H16ClO5PS. Formula Weight: 362.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Slightly soluble. SMILES: O=C1C(Cl)=C(C)C2=CC=C(OP(OCC)(OCC)=S)C=C2O1. InChi Code: InChI=1S/C14H16ClO5PS/c1-4-17-21(22,18-5-2)20-10-6-7-11-9(3)13(15)14(16)19-12(11)8-10/h6-8H,4-5H2,1-3H3. InChi Key: BXNANOICGRISHX-UHFFFAOYSA-N.