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White to off-white powder. Soluble in water, ethanol or DMSO. Chemical. CAS: 73-03-0. Formula: C10H13N5O3. MW: 251.24. Synthetic. Cordycepin is a nucleoside (adenosine analog) antibiotic that acts as a polyadenylation inhibitor when converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA and RNA synthesis. Cordycepin has a broad spectrum of biological activities, including anticancer, anti-proliferative, pro-apoptotic, anti-inflammatory and antifungal effects. It was shown to modulate autophagy and NLRP3 inflammasome. Cordycepin has been shown to reduce poly(A) tail length in mRNA, to activate AMPK kinase, leading to a reduction in mTOR signalling, downregulate ERK/Akt/PI3K/GSK-3beta/beta-catenin signaling pathways. Also useful for the study of messenger RNA transcription.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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