Complex 3

Complex 3 is a fluorescent dithiocarbazate-copper complex with anticancer activity. It localizes to mitochondria and displays excitation/emission maxima of 455-495/535 nm, respectively. Complex 3 inhibits the growth of BxPC-3, AsPC-1, PANC-1, and WI38 pancreatic cancer cells (IC50s = 0.74, 0.41, 0.62, and 2.06 µM, respectively). It induces lipid peroxidation and mitochondrial rupture and shrinkage in AsPC-1 cells, effects that can be reduced by the ferroptosis inhibitor liproxstatin-1 (Cay-17730). Complex 3 also induces mitochondrial apoptosis and cytokine-cytokine receptor interaction dysfunction in the same cells. In vivo, complex 3 (1.5 and 3 mg/kg) reduces tumor volume and intratumor apoptosis in an AsPC-1 mouse xenograft model.Formal Name: tribromobis[µ-[methyl N-[di(2-pyridinyl-kappaN)methylene]carbonodithiohydrazonato-kappaN,kappaS']]tri-copper. CAS Number: 2480150-28-3. Molecular Formula: C26H22Br3Cu3N8S4. Formula Weight: 1005.1. Purity: >90%. Emission: 535 nm. Excitation: 455-495 nm. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml. SMILES: [Br-][Cu+2]1([S-]2)[N](N=C2SC)=C(C3=CC=CC=[N]3[Cu+]([N]4=CC=CC=C4C(C5=CC=CC=[N]56)=[N](N=C7SC)[Cu+2]6([S-]7)[Br-])[Br-])C8=CC=CC=[N]81. InChi Code: InChI=1S/2C13H12N4S2.3BrH.3Cu/c2*1-19-13(18)17-16-12(10-6-2-4-8-14-10)11-7-3-5-9-15-11,,,,,,/h2*2-9H,1H3,(H,17,18),3*1H,,,/q,,,,,+1,2*+2/p-5. InChi Key: ICCMZVFKEUFYKQ-UHFFFAOYSA-I.