Combrestatin A4

Combrestatin A4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10007412-5 5 mg -

6 - 10 business days*

Cay10007412-10 10 mg -

6 - 10 business days*

Cay10007412-25 25 mg -

6 - 10 business days*

Cay10007412-50 50 mg -

6 - 10 business days*

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong... more
Product information "Combrestatin A4"
Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 µM. Formal Name: 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol. CAS Number: 117048-59-6. Synonyms: CA4, Combretastatin A4, CRC 87-09. Molecular Formula: C18H20O5. Formula Weight: 316.4. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2)(1:10): 0.1 mg/ml. lambdamax: 222, 296 nm. SMILES: COc1cc(\C=C\c2ccc(OC)c(O)c2)cc(OC)c1OC. InChi Code: InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-. InChi Key: HVXBOLULGPECHP-WAYWQWQTSA-N.
Keywords: CA4, Combretastatin A4, CRC 87-09, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol
Supplier: Cayman Chemical
Supplier-Nr: 10007412


Application: Tubulin polymerization inhibitor
MW: 316.4 D
Formula: C18H20O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 117048-59-6| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301+311+331, H318
P Phrases: , P280, P305+351+338, P310
Our products are for laboratory research use only: Not for administration to humans!
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