Colchicoside

Colchicoside is a glycoside form of 3-demethylcolchicine that has been found in G. superba. Unlike cholchicine and 3-demethylcolchicine, colchicoside does not displace [3H]-colchicine from rat brain tubulin in vitro when used at a concentration of 25 µM. Colchicoside (1 and 10 µM) increases levels of the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2E1 in primary human hepatocytes.Formal Name: N-[(7S)-3-(beta-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide. CAS Number: 477-29-2. Synonyms: 3-Demethylcolchicine glucoside. Molecular Formula: C27H33NO11. Formula Weight: 547.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 244, 247 nm. SMILES: O[C@H]([C@H]1O)[C@H](O)[C@@H](CO)O[C@H]1OC2=CC3=C(C(C([C@@H](NC(C)=O)CC3)=C4)=CC=C(OC)C4=O)C(OC)=C2OC. InChi Code: InChI=1S/C27H33NO11/c1-12(30)28-16-7-5-13-9-19(38-27-24(34)23(33)22(32)20(11-29)39-27)25(36-3)26(37-4)21(13)14-6-8-18(35-2)17(31)10-15(14)16/h6,8-10,16,20,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16?,20-,22-,23+,24-,27-/m1/s1. InChi Key: UXAFRQPVHYZDED-HMZBFJTNSA-N. Origin: Natural/Source unknown.