Cobaltic(III) Protoporphyrin IX Chloride

Cobaltic(III) protoporphyrin IX chloride is a metalloporphyrin and an inducer of heme oxygenase-1 (HO-1) activity. Unlike other metalloporphyrins, cobaltic(III) protoporphyrin IX chloride induces activity of HO-1, the rate-limiting enzyme in heme catabolism, in vitro and in vivo. It also reduces the activity of delta-aminolevulinate synthase, the enzyme that catalyzes the rate-limiting step of heme biosynthesis, as well as decreases the activity of cytochrome P450 (CYP), in rat liver microsomes ex vivo when administered at a dose of 125 µmol/kg. Cobaltic(III) protoporphyrin IX chloride (5 mg/kg) prevents liver injury and increases in the percentage of hepatic apoptotic cells in a mouse model of liver ischemia-reperfusion injury. It increases survival and decreases the number of lung colony forming units (CFUs) in mice infected with Y. pestis at the same dose. Cobaltic(III) protoporphyrin IX chloride has also been used as a catalyst for the electrochemical reduction of carbon dioxide in carbon electrodes.Formal Name: (SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24]-cobaltate(2-), dihydrogen. CAS Number: 102601-60-5. Synonyms: Cobaltic Protoporphyrin IX Chloride. Molecular Formula: C34H30ClCoN4O4 . 2H. Formula Weight: 655.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 234, 420 nm. SMILES: [Cl-][Co+3]1([N](C2=C3)=C(C(C=C)=C2C)C=C4C(C)=C5CCC([O-])=O)([N-]6C3=C7C=C)[N-]4C5=CC(C(CCC([O-])=O)=C8C)=[N]1C8=CC6=C7C.[H+].[H+]. InChi Code: InChI=1S/C34H34N4O4.ClH.Co/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25,,/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42),1H,/q,,+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-,,. InChi Key: WWNXKQFLDNSNDN-HXFTUNQESA-K.