Cnidicin

Description: Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT-15 (colon) in vitro . Target: NOS, NO Synthase. Smiles: CC(C)=CCOc1c2ccoc2c(OCC=C(C)C)c2oc(=O)ccc12. References: Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines.Phytother Res. 2007 Mar,21(3):288-90.