CN128

CN128 is an orally bioavailable iron chelator. It contains a side chain hydroxy group that acts as an alternate sacrificial glucuronidation site to alleviate metabolic inactivation at the 3-hydroxy group. CN128 increases iron mobilization by 24.8% in a 59Fe-ferritin-loaded rat model of iron overload when administered at doses of 150 and 450 µmol/kg.Formal Name: 3,4-dihydroxy-1-[(1R)-1-(hydroxymethyl)-2-phenylethyl]-2-methyl-pyridinium. CAS Number: 2457170-98-6. Synonyms: R-CN128. Molecular Formula: C15H18NO3. Formula Weight: 260.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: 5 mg/ml, Methanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 287 nm. SMILES: OC1=C(O)C(C)=[N+]([C@@H](CO)CC2=CC=CC=C2)C=C1. InChi Code: InChI=1S/C15H17NO3/c1-11-15(19)14(18)7-8-16(11)13(10-17)9-12-5-3-2-4-6-12/h2-8,13,17,19H,9-10H2,1H3/p+1/t13-/m1/s1. InChi Key: FAYRGKKCBATAET-CYBMUJFWSA-O.