CM11
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A PROTAC that drives VHL degradation, selectively induces the degradation of pVHL30 over pVHL19... more
Product information "CM11"
A PROTAC that drives VHL degradation, selectively induces the degradation of pVHL30 over pVHL19 and a panel of 6,449 proteins in HeLa cells at 1 µM but does decrease protein levels of Cul-2. Formulation: A solid. InChI: InChI=1S/C58H82N8O14S2/c1-37-49(81-35-61-37)41-13-9-39(10-14-41)29-59-53(71)45-27-43(67)31-65(45)55(73)51(57(3,4)5)63-47(69)33-79-25-23-77-21-19-75-17-18-76-20-22-78-24-26-80-34-48(70)64-52(58(6,7)8)56(74)66-32-44(68)28-46(66)54(72)60-30-40-11-15-42(16-12-40)50-38(2)62-36-82-50/h9-16,35-36,43-46,51-52,67-68H,17-34H2,1-8H3,(H,59,71)(H,60,72)(H,63,69)(H,64,70)/t43-,44-,45+,46+,51-,52-/m1/s1. InChIKey: WGJCHHJGGFCCRS-DEYDLUNASA-N. SMILES: O=C([C@@H](NC(COCCOCCOCCOCCOCCOCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O)=O)C(C)(C)C)N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@H](C4)O
| Keywords: | (4R,4'R)-1,1'-(1,20-dioxo-3,6,9,12,15,18-hexaoxaeicosane-1,20-diyl)bis[3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 41885 |
Properties
| Application: | VHL degrading PROTAC |
| MW: | 1179.5 D |
| Formula: | C58H82N8O14S2 |
| Purity: | >95% |
| Format: | Solid |
Database Information
| CAS : | 2244684-49-7| Matching products |
| KEGG ID : | K03871 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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