Cloxacillin (sodium salt)

Cloxacillin is a beta-lactam antibiotic and a derivative of oxacillin (Cay-23954). It is active against clinical isolates of the Gram-positive bacteria S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 µg/ml, respectively) but not 34 Gram-negative bacteria (MICs = >128 µg/ml for all). Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC50s = 0.04, 0.12, 0.21, and 2.5 µg/ml, respectively). It also binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 µM, respectively). Cloxacillin decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection.Formal Name: (2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt. CAS Number: 642-78-4. Molecular Formula: C19H17ClN3O5S . Na. Formula Weight: 457.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 16 mg/mL, Ethanol: 2 mg/mL, PBS (pH 7.2): 10 mg/mL. SMILES: CC1(C)[C@H](C([O-])=O)N2C([C@@H](NC(C3=C(C)ON=C3C4=CC=CC=C4Cl)=O)[C@@]2([H])S1)=O.[Na+]. InChi Code: InChI=1S/C19H18ClN3O5S.Na/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23,/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27),/q,+1/p-1/t13-,14+,17-,/m1./s1. InChi Key: SCLZRKVZRBKZCR-SLINCCQESA-M.