Clofazimine-d7

Clofazimine-d7 is intended for use as an internal standard for the quantification of clofazimine (Cay-23301) by GC- or LC-MS. Clofazimine is an antimycobacterial compound with MICs ranging from 0.03 to 0.12 µg/ml against clinical isolates of M. paratuberculosis. It also has activity against 80 isolates of M. fortuitum, M. chelonae, and M. fallax (MICs = =0.25-8 µg/ml). Clofazimine (25 mg/kg per day) reduces the number of M. tuberculosis-infected cells in the spleen and lungs of mice infected with the multidrug-resistant clinical isolate strain CNL. Formulations containing clofazimine have been used for the treatment of leprosy and drug-resistant tuberculosis.Formal Name: (E)-N,5-bis(4-chlorophenyl)-3-((propan-2-yl-d7)imino)-3,5-dihydrophenazin-2-amine. Molecular Formula: C27H15Cl2D7N4. Formula Weight: 480.4. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Slightly soluble (*heated). SMILES: ClC(C=C1)=CC=C1NC2=CC3=NC4=CC=CC=C4N(C5=CC=C(Cl)C=C5)C3=C/C2=N\C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H]. InChi Code: InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+/i1D3,2D3,17D. InChi Key: WDQPAMHFFCXSNU-SXUGDVLYSA-N.