Clindamycin-d3 (hydrochloride)

Clindamycin-d3 is intended for use as an internal standard for the quantification of clindamycin (Cay-15006, Cay-35581) by GC- or LC-MS. Clindamycin is a lincosamide antibiotic. It is active against Gram-positive bacteria, including various strains of S. pneumoniae, S. viridans, S. aureus, and S. epidermidis (MICs = 0.002-0.1, 0.005-0.2, 0.04-1.6, and 0.1-0.2 µg/ml, respectively). Clindamycin is also active against chloroquine-resistant and -sensitive strains of P. falciparum (IC50s = 3.12 and 8.81 nM, respectively). It inhibits bacterial protein synthesis by interacting with the 50S ribosome. Clindamycin increases survival in a mouse model of a secondary S. pneumoniae infection when administered at a dose of 15 mg/kg twice daily for seven days. Formulations containing clindamycin have been used in the treatment of bacterial infections.Formal Name: (2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-(methyl-d3)-4-propylpyrrolidine-2-carboxamide, monohydrochloride. CAS Number: 1356933-72-6. Molecular Formula: C18H30D3ClN2O5S . HCl. Formula Weight: 464.5. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Water: soluble. SMILES: O=C([C@@H]1C[C@H](CN1C([2H])([2H])[2H])CCC)N[C@@H]([C@@]2([H])O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C.Cl. InChi Code: InChI=1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4,/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25),1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+,/m0./s1/i3D3,. InChi Key: AUODDLQVRAJAJM-LXHDSOSYSA-N.