Clevidipine-d7

Clevidipine-d7 is intended for use as an internal standard for the quantification of clevidipine (Cay-23025) by GC- or LC-MS. Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes). It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively). Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.Formal Name: 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(1-oxobutoxy-d7)methyl] ester. CAS Number: 2747918-66-5. Synonyms: rac-Clevidipine-d7. Molecular Formula: C21H16Cl2D7NO6. Formula Weight: 463.4. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: O=C(C1=C(C)NC(C)=C(C1C2=C(Cl)C(Cl)=CC=C2)C(OCOC(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O)OC. InChi Code: InChI=1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3/i1D3,5D2,7D2. InChi Key: KPBZROQVTHLCDU-ISARVPQGSA-N.