CL 316243

Description: CL316243 is a highly potent and selective agonist of beta3-adrenoceptor with an EC50 of 3 nM. It effectively stimulates adipocyte lipolysis, increases brown adipose tissue thermogenesis and metabolic rate, and holds potential for the treatment of obesity, diabetes, and [urge urinary incontinence]. Target: Adrenergic Receptor. Smiles: [Na+].[Na+].C[C@H](Cc1ccc2OC(Oc2c1)(C([O-])=O)C([O-])=O)NC[C@H](O)c1cccc(Cl)c1. References: Bloom JD, et al. Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.J Med Chem. 1992 Aug 7,35(16):3081-4.