CL 218,872

CL 218,872 is an anxiolytic agent. It selectively binds to alpha1beta1gamma2 subunit-containing GABAA receptors over alpha2beta1gamma2 or alpha3beta1gamma2 subunit-containing GABAA receptors (Kis = 0.131, 1.82, and 1.53 µM, respectively). CL 218,872 increases drinking in the Vogel punished drinking task and inhibits foot-shock-induced fighting, indicating anxiolytic-like activities, in mice in a dose-dependent manner. It also increases the duration of pentobarbitone-induced anesthesia, reduces spontaneous locomotor activity, and inhibits convulsions induced by pentylenetetrazole (PTZ, Cay-18682), picrotoxin (Cay-20771), or bicuculline (Cay-11727) with ED50 values of 12.8, 28.5, and 35.3 mg/kg, respectively, in mice.Formal Name: 3-methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine. CAS Number: 66548-69-4. Molecular Formula: C13H9F3N4. Formula Weight: 278.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 247 nm. SMILES: FC(F)(C1=CC=CC(C2=NN3C(C=C2)=NN=C3C)=C1)F. InChi Code: InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3. InChi Key: GUOQUXNJZHGPQF-UHFFFAOYSA-N.