Cirazoline (hydrochloride)

Cirazoline is an alpha1-adrenergic receptor (alpha1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant alpha1A-, alpha1B-, and alpha1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at alpha1A- and a partial agonist at alpha1B- and alpha1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at alpha2-ARs with a pA2 value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum. Cirazoline (0.01-1 µg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months. It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 µg/kg but impairs performance at lower doses of 0.01-1 µg/kg.Formal Name: 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole, monohydrochloride. CAS Number: 40600-13-3. Molecular Formula: C13H16N2O . HCl. Formula Weight: 252.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 33 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: [H]N1CCN=C1COC2=CC=CC=C2C3CC3.Cl. InChi Code: InChI=1S/C13H16N2O.ClH/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13,/h1-4,10H,5-9H2,(H,14,15),1H. InChi Key: XFRXWLWUUDJHPB-UHFFFAOYSA-N.