Cinnabarinic Acid

Cinnabarinic acid is an agonist of metabotropic glutamate receptor 4 (mGluR4) and active metabolite of 3-hydroxyanthranilic acid. It is formed via two-step oxidation of 3-hydroxyanthranilic acid. Cinnabarinic acid (100 µM) selectively induces inositol phosphate production in HEK293 cells expressing mGluR4 over HEK293 cells expressing mGluR1, mGluR2, mGluR5, mGluR6, mGluR7, or mGluR8. It inhibits D-amino acid oxidase (DAAO) in a cell-free assay (IC50 = 1.37 µM). Cinnabarinic acid (30 µM) increases levels of reactive oxygen species (ROS) and induces apoptosis in primary mouse thymocytes.Formal Name: 2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid. CAS Number: 606-59-7. Molecular Formula: C14H8N2O6. Formula Weight: 300.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 25 mM (warmed). SMILES: O=C1C(N)=C(C(O)=O)C2=NC3=C(C=CC=C3C(O)=O)OC2=C1. InChi Code: InChI=1S/C14H8N2O6/c15-10-6(17)4-8-12(9(10)14(20)21)16-11-5(13(18)19)2-1-3-7(11)22-8/h1-4H,15H2,(H,18,19)(H,20,21). InChi Key: FSBKJYLVDRVPTK-UHFFFAOYSA-N.