CID-5157334

CID-5157334 is a surrogate agonist of G protein-coupled receptor 27 (GPR27). It induces recruitment of beta-arrestin-2 in complementation assays using wild-type GPR27 or a GPR27-vasopressin 2 (GPR27V2) chimeric receptor (EC50s = 7.943 and 0.417 nM, respectively) but does not induce recruitment of beta-arrestin-1 in the same assay or activation of the Gq, Gs, or Gi signaling pathways in aequorin-GFP assays. CID-5157334 is selective for GPR27 over GPR85V2 and GPR173V2 chimeric receptors at 15 µM.Formal Name: 2,4-dichloro-N-[4-[(phenylamino)sulfonyl]phenyl]-benzamide. CAS Number: 651295-98-6. Synonyms: CID-5128535. Molecular Formula: C19H14Cl2N2O3S. Formula Weight: 421.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: ClC(C=C1Cl)=CC=C1C(NC(C=C2)=CC=C2S(NC3=CC=CC=C3)(=O)=O)=O. InChi Code: InChI=1S/C19H14Cl2N2O3S/c20-13-6-11-17(18(21)12-13)19(24)22-14-7-9-16(10-8-14)27(25,26)23-15-4-2-1-3-5-15/h1-12,23H,(H,22,24). InChi Key: LNUTUGZHBGDTOU-UHFFFAOYSA-N.