CID-25014542

A LRRK2 inhibitor (IC50 = 15 nM), selective for LRRK2 over a panel of 44 other kinases but does inhibit MAPK4 and Pim-2 at 1 µM, inhibits FLT3 at 10 µM, decreases the production of Abeta42 in a reporter assay using H4 cells overexpressing Abeta42 (IC50 = 15 µM), inhibits EGF-induced activation of MAPK in serum-starved cells at 20 µM, increases the survival of primary rat granule neurons in low potassium media at 1, 5, or 25 µM. Formulation: A solid. InChI: InChI=1S/C15H8Br2ClNO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-. InChIKey: MPIHOJMBMIMKAJ-KMKOMSMNSA-N. SMILES: ClC1=CC=C2C(/C(C(N2)=O)=C/C3=CC(Br)=C(O)C(Br)=C3)=C1