CID-1375606

CID-1375606 is a GPR27 agonist with EC50 values of 0.46 µM and 7.9 µM in chimeric GPR27V2 and wild-type GPR27 luciferase beta-arrestin-2 complementation assays, respectively. It is selective for GPR27 over the closely related receptors GPR85 and GPR173 for which it does not induce beta-arrestin-2 recruitment in the same assay. GPR27 function has been linked to insulin promoter activity and excretion.Formal Name: 2,4-dichloro-N-[4-[(phenylamino)carbonyl]phenyl]-benzamide. CAS Number: 313493-80-0. Molecular Formula: C20H14Cl2N2O2. Formula Weight: 385.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml. lambdamax: 290 nm. SMILES: O=C(C1=CC=C(NC(C2=CC=C(Cl)C=C2Cl)=O)C=C1)NC3=CC=CC=C3. InChi Code: InChI=1S/C20H14Cl2N2O2/c21-14-8-11-17(18(22)12-14)20(26)24-16-9-6-13(7-10-16)19(25)23-15-4-2-1-3-5-15/h1-12H,(H,23,25)(H,24,26). InChi Key: PFHDXBXPRBQVAV-UHFFFAOYSA-N.