Choline (chloride)

Choline is an essential nutrient with roles in liver, neurological, hematological, and skeletal muscle homeostasis. It is a precursor in the biosynthesis of membrane phospholipids, such as phosphatidylcholine, which facilitate cell signaling and transport across the membrane, and a precursor to the neurotransmitter acetylcholine. Choline is required for hepatic lipid transport. Perinatal administration of choline (18.8 mg/kg) improves prenatal alcohol exposure-induced cognitive deficits in rats. Choline (13 mg/animal per day) improves motor coordination and behavioral deficits in a mouse model of Rett syndrome, as well as improves deficits in recognition memory induced by early-life iron deficiency in rats when administered in the drinking water at a concentration of 5 ppm. Deficiencies in choline intake are positively correlated with muscle wasting, and dietary administration of choline (1,000 mg/kg) increases leg and breast muscle protein content in broiler chickens.Formal Name: 2-hydroxy-N,N,N-trimethyl-ethanaminium, monochloride. CAS Number: 67-48-1. Molecular Formula: C5H14NO . Cl. Formula Weight: 139.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. SMILES: OCC[N+](C)(C)C.[Cl-]. InChi Code: InChI=1S/C5H14NO.ClH/c1-6(2,3)4-5-7,/h7H,4-5H2,1-3H3,1H/q+1,/p-1. InChi Key: SGMZJAMFUVOLNK-UHFFFAOYSA-M.