Cholestyramine Resin

Cholestyramine resin is a anion-exchange resin polymer. This resin is a bile acid sequestrant that interchanges chloride anions for bile acids of the small intestine lumen, leading to excretion of bile acids in the feces and reduced levels of serum bile acid. The resin induces dose-dependent reduction of low-density lipid (LDL) cholesterol. In laboratory research, cholestyramine resin serves as a versatile tool for the removal of bile salts, free fatty acids, endotoxins, and other anionic contaminants from biological samples or culture media. Its robust binding properties also make it useful for studying lipid metabolism, drug absorption, and detoxification processes. Cholestyramine resin is used in protein chromatography, ion exchange chromatography and anion exchange media.