Chlorambucil-d8

Chlorambucil-d8 is intended for use as an internal standard for the quantification of chlorambucil (Cay-23744) by GC- or LC-MS. Chlorambucil is a DNA alkylating agent. It induces DNA cross-linking in vitro when used at a concentration of 1 mg/ml and preferentially targets guanine-rich regions. Chlorambucil (8 and 15 mg/kg) is teratogenic in vivo, reducing fetal brain size and inducing microcephaly when administered to pregnant mice. Formulations containing chlorambucil have been used in the treatment of various cancers.Formal Name: 4-[bis(2-chloroethyl)amino-d8]-benzenebutanoic acid. CAS Number: 2748247-26-7. Molecular Formula: C14H11D8Cl2NO2. Formula Weight: 312.3. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: OC(CCCC1=CC=C(N(C([2H])([2H])C([2H])([2H])Cl)C([2H])([2H])C([2H])([2H])Cl)C=C1)=O. InChi Code: InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)/i8D2,9D2,10D2,11D2. InChi Key: JCKYGMPEJWAADB-JNJBWJDISA-N.