Chlorambucil

Chlorambucil is a DNA alkylating agent. It induces DNA cross-linking in vitro when used at a concentration of 1 mg/ml and preferentially targets guanine-rich regions. Chlorambucil (8 and 15 mg/kg) is teratogenic in vivo, reducing fetal brain size and inducing microcephaly when administered to pregnant mice. Formulations containing chlorambucil have been used in the treatment of various cancers.Formal Name: 4-[bis(2-chloroethyl)amino]-benzenebutanoic acid. CAS Number: 305-03-3. Synonyms: CB-1348, NCI 3088, NSC 3088. Molecular Formula: C14H19Cl2NO2. Formula Weight: 304.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: OC(CCCC1=CC=C(N(CCCl)CCCl)C=C1)=O. InChi Code: InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19). InChi Key: JCKYGMPEJWAADB-UHFFFAOYSA-N.