CGS 9343B

CGS 9343B is a calmodulin inhibitor. It inhibits calmodulin-induced phosphodiesterase (PDE) activity (IC50 = 3.3 µM) but does not inhibit basal PKC activity at 100 µM. CGS 9343B (120 µM) inhibits calcium release induced by inositol 1,4,5-trisphosphate (IP3) in 261B rat liver epithelial cells. It reduces the incidence of diarrhea without affecting gastrointestinal transit time in a mouse model of secretory diarrhea induced by castor oil when administered at a dose of 3 mg/kg.Formal Name: 1,3-dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one, 2Z-butenedioate. CAS Number: 109826-27-9. Synonyms: KW-5617, Zaldaride Maleate. Molecular Formula: C26H28N4O2 . C4H4O4. Formula Weight: 544.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: slightly soluble, warmed. SMILES: CC1(C2=CC=CN2C3=CC=CC=C3CO1)CN4CCC(N5C(NC6=CC=CC=C65)=O)CC4.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C26H28N4O2.C4H4O4/c1-26(24-11-6-14-29(24)22-9-4-2-7-19(22)17-32-26)18-28-15-12-20(13-16-28)30-23-10-5-3-8-21(23)27-25(30)31,5-3(6)1-2-4(7)8/h2-11,14,20H,12-13,15-18H2,1H3,(H,27,31),1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: NGODOSILXOFQPH-BTJKTKAUSA-N.