Cerivastatin sodium

Description: Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM) that inhibits the proliferation and invasiveness of MDA-MB-231 cells, primarily through RhoA inhibition. Target: HMG-CoA Reductase. Smiles: COCc1c(nc(C(C)C)c(C=CC(O)CC(O)CC(O)=O)c1-c1ccc(F)cc1)C(C)C. References: Denoyelle C, et al. Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. Carcinogenesis. 2001 Aug,22(8):1139-48.