Cephalotaxine

Cephalotaxine is an alkaloid that has been found in Cephalotaxus and has anticancer and antiviral activities. It is cytotoxic to HL-60, NB4, MOLT-4, K562, Jurkat, and Raji cells (IC50s = 4.91, 16.88, 7.09, 22.59, 5.54, and 18.08 µM, respectively). Cephalotaxine (5-20 µM) induces mitochondrial apoptosis, as well as impairs lysosomal acidification and autophagic flux in HL-60 cells. It reduces infectivity and hepatitis B virus (HBV) surface antigen (HBsAg) secretion in HBV-infected HepG2 2.2.15 cells when used at concentrations ranging from 10 to 100 µM. Cephalotaxine (20, 40, and 80 µM) also reduces viral infectivity in Zika virus-infected Vero cells.CAS Number: 24316-19-6. Synonyms: (-)-Cephalotaxine, NSC 128487, NSC 245454, ZINC19795976. Molecular Formula: C18H21NO4. Formula Weight: 315.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/mL, DMSO: 12 mg/mL, Ethanol: 5 mg/mL. SMILES: O[C@H]1[C@]2([H])[C@]3(C=C1OC)N(CCC3)CCC4=CC(OCO5)=C5C=C42. InChi Code: InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1. InChi Key: YMNCVRSYJBNGLD-KURKYZTESA-N. Origin: Plant/Taxus wallichiana.