Cedazuridine

Cedazuridine is an inhibitor of cytidine deaminase (IC50 = 0.4 µM). It increases plasma levels of decitabine via inhibition of its metabolism by cytidine deaminase in rhesus monkeys when administered at doses of 1 and 10 mg/kg. Cedazuridine (3 mg/kg) induces decreases in leukemic cell expansion in combination with orally administered 5-azacytidine (Cay-11164), which is inactive as a single agent, in the bone marrow and spleen in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model. Formulations containing cedazuridine in combination with decitabine have been used in the treatment of myelodysplastic syndrome (MDS).Formal Name: (4R)-2'-deoxy-2',2'-difluoro-3,4,5,6-tetrahydro-uridine. CAS Number: 1141397-80-9. Synonyms: E7727. Molecular Formula: C9H14F2N2O5. Formula Weight: 268.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble. SMILES: FC1([C@H](N2C(N[C@@H](CC2)O)=O)O[C@@H]([C@H]1O)CO)F. InChi Code: InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5-,6-,7-/m1/s1. InChi Key: VUDZSIYXZUYWSC-DBRKOABJSA-N.