Ceapin-A7

Ceapin-A7 is an inhibitor of activating transcription factor 6alpha (ATF6alpha, IC50 = 0.59 µM in a reporter assay). It is selective for ATF6alpha over ATF6beta at 18.9 µM. Ceapin-A7 (6 µM) sensitizes U2OS osteosarcoma cells to the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor and ER stress inducer thapsigargin (Cay-10522). Chondrocyte-conditioned media from primary human chondrocytes pre-incubated with ceapin-A7 (0.5 µM) prior to stimulation with TNF-alpha, IFN-gamma, or IL-17 has a reduced ability to induce tube formation in human umbilical vein endothelial cells (HUVECs). Ceapin-A7 (15 µM) inhibits viral RNA production in Vero cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Formal Name: N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-3-isoxazolecarboxamide. CAS Number: 2323027-38-7. Molecular Formula: C20H12F6N4O3. Formula Weight: 470.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 1 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. SMILES: FC(F)(F)C1=CC(C(F)(F)F)=CC=C1CN2N=CC(NC(C3=NOC(C4=CC=CO4)=C3)=O)=C2. InChi Code: InChI=1S/C20H12F6N4O3/c21-19(22,23)12-4-3-11(14(6-12)20(24,25)26)9-30-10-13(8-27-30)28-18(31)15-7-17(33-29-15)16-2-1-5-32-16/h1-8,10H,9H2,(H,28,31). InChi Key: UJTDYOXTXGBHEG-UHFFFAOYSA-N.