CCVJ

Fluorescent molecular rotors are molecules whose fluorescence is inversely proportional to its intramolecular rotation. The intramolecular rotation of these probes, and hence their fluorescence, depends on the immediate microenvironment of the probe. As a result, fluorescent molecular rotors are used to evaluate changes in solution and membrane viscosity, polymerization or aggregation processes, and protein (un)folding. CCVJ is a fluorescent molecular rotor characterized by low background fluorescence, low fluorescence anisotropy, and good water solubility. Moreover, CCVJ has large hydrophobic structures, allowing it to associate in a non-covalent manner with hydrophobic pockets in proteins in solution. CCVJ is broadly used to monitor changes in solution and molecular characteristics.Formal Name: 2-cyano-3-(2,3,6,7-tetrahydro-1H,5H-benzo[ij]quinolizin-9-yl)-2-propenoic acid. CAS Number: 142978-18-5. Synonyms: 9-(2-Carboxy-2-cyanovinyl)julolidine. Molecular Formula: C16H16N2O2. Formula Weight: 268.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml. lambdamax: 279, 441 nm. SMILES: OC(/C(C#N)=C/C1=CC(CCC2)=C(N2CCC3)C3=C1)=O. InChi Code: InChI=1S/C16H16N2O2/c17-10-14(16(19)20)9-11-7-12-3-1-5-18-6-2-4-13(8-11)15(12)18/h7-9H,1-6H2,(H,19,20)/b14-9+. InChi Key: JXENNHTVELFRHV-NTEUORMPSA-N.