CCG-232601

CCG-232601 is an inhibitor of the Rho/MRTF/SRF transcriptional pathway and a derivative of CCG-203971 (Cay-15075). CCG-232601 inhibits MRTF-dependent transcription in HEK293T cells (IC50 = 0.55 µM in a luciferase reporter assay). It also reduces expression of alpha-smooth muscle actin (alpha-SMA) in TGF-beta-stimulated human dermal fibroblasts to 31% of control when used at a concentration of 10 µM. CCG-232601 (50 mg/kg) inhibits increases in dermal thickness and hydroxyproline content in a mouse model of dermal fibrosis induced by bleomycin (Cay-13877).Formal Name: N-(4-chlorophenyl)-5,5-difluoro-1-[3-(4-pyridinyl)benzoyl]-3-piperidinecarboxamide. CAS Number: 1922099-21-5. Molecular Formula: C24H20ClF2N3O2. Formula Weight: 455.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 250 nm. SMILES: O=C(N1CC(F)(F)CC(C(NC2=CC=C(Cl)C=C2)=O)C1)C3=CC(C4=CC=NC=C4)=CC=C3. InChi Code: InChI=1S/C24H20ClF2N3O2/c25-20-4-6-21(7-5-20)29-22(31)19-13-24(26,27)15-30(14-19)23(32)18-3-1-2-17(12-18)16-8-10-28-11-9-16/h1-12,19H,13-15H2,(H,29,31). InChi Key: MKJLDLGLVZUENS-UHFFFAOYSA-N.