CCCP

CCCP is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. It inhibits mitochondrial respiration and ATPase activity when used at concentrations of 110 and 35 nM, respectively. CCCP inhibits activation of stimulation of interferon genes (STING), decreasing the expression of downstream STING targets, including IFN-beta, TBK1, and IRF3 when used at a concentration of 50 µM in RAW 264.7 cells. It induces mitochondrial fission in a manner dependent on the GTPase Drp1. CCCP (4 mg/kg) increases body temperature as well as left ventricular systolic and diastolic dimensions and decreases fractional shortening in rats. It also increases myocardial glucose and fatty acid uptake in rats.Formal Name: 2-[2-(3-chlorophenyl)hydrazinylidene]-propanedinitrile. CAS Number: 555-60-2. Synonyms: Carbonyl cyanide m-chlorophenyl hydrazone, NSC 88124. Molecular Formula: C9H5ClN4. Formula Weight: 204.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 0.1 mg/ml. lambdamax: 248, 353 nm. SMILES: ClC1=CC=CC(N/N=C(C#N)\C#N)=C1. InChi Code: InChI=1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H. InChi Key: UGTJLJZQQFGTJD-UHFFFAOYSA-N.