CC-671

CC-671 is a dual inhibitor of the spindle assembly checkpoint kinase Mps1/TTK and Cdc2-like kinase (Clk2, IC50s = 5 and 3 nM, respectively). It is selective for Mps1/TTK and Clk2 over a panel of 255 kinases at 3 µM, but does inhibit DYRK3, DYRK1A, PHKG, DYRK1B, and Clk1 (IC50s = 99, 104, 136, 157, and 300 nM, respectively). CC-671 selectively inhibits the growth of Cal-51 triple negative breast cancer (TNBC) cells over BT-474 luminal breast cancer cells (IC50s = 60 and 6,970 nM, respectively). In vivo, CC-671 (20 mg/kg) reduces tumor volume in a Cal-51 mouse xenograft model.Formal Name: 4-[[4-(cyclopentyloxy)-5-(2-methyl-6-benzoxazolyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methyl-benzamide. CAS Number: 1618658-88-0. Molecular Formula: C28H28N6O4. Formula Weight: 512.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 10 mg/ml. lambdamax: 282, 326 nm. SMILES: COC(C=C(C(NC)=O)C=C1)=C1NC2=NC(OC3CCCC3)=C(C(C4=CC=C(N=C(C)O5)C5=C4)=CN6)C6=N2. InChi Code: InChI=1S/C28H28N6O4/c1-15-31-21-10-8-16(12-23(21)37-15)19-14-30-25-24(19)27(38-18-6-4-5-7-18)34-28(33-25)32-20-11-9-17(26(35)29-2)13-22(20)36-3/h8-14,18H,4-7H2,1-3H3,(H,29,35)(H2,30,32,33,34). InChi Key: CWJLAVRXVFHDSJ-UHFFFAOYSA-N.