CAY10583

Description: CAY10583 is an agonist of leukotriene B4 receptor type 2 (BLT2). CAY10583 directly promotes keratinocyte migration and indirectly enhances fibroblast proliferation by increasing keratinocyte production of bFGF1 and TGF-beta, leadng to accelerate wound closure. Target: Others. Smiles: C(O)(=O)C1=C(C=CC=C1)C2=CC=C(CN(C(CCCC)=O)C3=CC=CC=C3)C=C2. References: Luo L, Tanaka R, Kanazawa S, Lu F, Hayashi A, Yokomizo T, Mizuno H. A synthetic leukotriene B(4) receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes. J Diabetes Complications. 2017 Jan,31(1):13-20. doi: 10.1016/j.jdiacomp.2016.09.002. PubMed PMID: 27742551.