CAY10561

CAY10561
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010043-500 500 µg -

6 - 10 business days*

25.00€
Cay10010043-1 1 mg -

6 - 10 business days*

48.00€
Cay10010043-5 5 mg -

6 - 10 business days*

200.00€
Cay10010043-10 10 mg -

6 - 10 business days*

350.00€
 
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse... more
Product information "CAY10561"
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 µM. Formal Name: N-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide. CAS Number: 933786-58-4. Synonyms: Pyrazolylpyrrole ERK Inhibitor. Molecular Formula: C22H17Cl2FN4O2. Formula Weight: 459.3. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMSO: 1.5 mg/ml, Ethanol: 5 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 270 nm. SMILES: [H]N1C(C2=CNC(C(NC(CO)C3=CC=C(F)C(Cl)=C3)=O)=C2)=C(C4=CC(Cl)=CC=C4)C=N1. InChi Code: InChI=1S/C22H17Cl2FN4O2/c23-15-3-1-2-12(6-15)16-10-27-29-21(16)14-8-19(26-9-14)22(31)28-20(11-30)13-4-5-18(25)17(24)7-13/h1-10,20,26,30H,11H2,(H,27,29)(H,28,31). InChi Key: YMUYGRBBEDYUOP-UHFFFAOYSA-N.
Keywords: Pyrazolylpyrrole ERK Inhibitor, N-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide
Supplier: Cayman Chemical
Supplier-Nr: 10010043

Properties

Application: ERK2 inhibitor
MW: 459.3 D
Formula: C22H17Cl2FN4O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 933786-58-4| Find alternatives
KEGG ID : K04371 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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