CAY10550

CAY10550
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010740-1 1 mg -

6 - 10 business days*

27.00€
Cay10010740-5 5 mg -

6 - 10 business days*

119.00€
Cay10010740-10 10 mg -

6 - 10 business days*

210.00€
Cay10010740-25 25 mg -

6 - 10 business days*

460.00€
 
Cellular prion protein (PrPc) is a cell surface glycoprotein expressed in brain, spinal cord, and... more
Product information "CAY10550"
Cellular prion protein (PrPc) is a cell surface glycoprotein expressed in brain, spinal cord, and several peripheral tissues that if mutated to the protease-resistant isoform PrPSc (scrapie PrP, PrPres) can result in one of several fatal neurodegenerative diseases. Prion diseases, including mad cow disease (bovine spongiform encephalopathy), scrapie, and Creutzfeldt-Jakob disease develop from the accumulation of PrPSc, an abnormally folded beta-rich conformation of PrPc. CAY10550 is a potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines. This compound also demonstrates moderate radical scavenging activity as it inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90 µM. Formal Name: 2,4-dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one. CAS Number: 34320-83-7. Synonyms: 3-(4-Nitrophenyl)-1-phenyl-2-pyrazolin-5-one. Molecular Formula: C15H11N3O3. Formula Weight: 281.3. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMS: 1 mg/ml, DMSO: 1 mg/ml. lambdamax: 242, 337 nm. SMILES: O=C1CC(=NN1c1ccccc1)c1ccc(cc1)[N+](=O)[O-]. InChi Code: InChI=1S/C15H11N3O3/c19-15-10-14(11-6-8-13(9-7-11)18(20)21)16-17(15)12-4-2-1-3-5-12/h1-9H,10H2. InChi Key: FDAVFKZPGQEGDX-UHFFFAOYSA-N.
Keywords: 3-(4-Nitrophenyl)-1-phenyl-2-pyrazolin-5-one, 2,4-dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one
Supplier: Cayman Chemical
Supplier-Nr: 10010740

Properties

Application: PrPc accumulation inhibitor
MW: 281.3 D
Formula: C15H11N3O3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 34320-83-7| Find alternatives
KEGG ID : K05634 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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