Casticin

Casticin is a flavonol isolated from A. annua, V. trifolia, and V. agnus-castus that decreases proliferation in K562, HL-60, and Kasumi-1 leukemia cell lines (IC50s = 5.95, 4.82, and 15.56 µM, respectively). It blocks TGF-beta/SMAD signaling in LX2 cells preventing activation, inhibiting proliferation, and inducing apoptosis of these hepatic stellate cells. In a mouse model of liver fibrosis, casticin (20 mg/kg) decreases TGF-beta1 mRNA and phosphorylated SMAD (p-SMAD) levels. Casticin induces apoptosis in hepatocellular carcinoma (HCC) and breast cancer cells. It also downregulates Twist and prevents the epithelial-mesenchymal transition (EMT) in human HCC SMMC-7721 cells.Formal Name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one. CAS Number: 479-91-4. Synonyms: Vitexicarpin. Molecular Formula: C19H18O8. Formula Weight: 374.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMF:PBS (pH 7.2) (1:5): 1 mg/mL, DMSO: 10 mg/mL, Ethanol: 5 mg/mL. lambdamax: 210, 258, 350 nm. SMILES: O=C1C2=C(O)C(OC)=C(OC)C=C2OC(C3=CC=C(OC)C(O)=C3)=C1OC. InChi Code: InChI=1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3. InChi Key: PJQLSMYMOKWUJG-UHFFFAOYSA-N.