Carmustine

Carmustine is a DNA alkylating agent. It inhibits cell growth and induces cell cycle arrest at the G2/M phase in C6 rat glioma cells when used at a concentration of 10 µM. In vivo, carmustine (0.3 and 6.7 mg/kg per day) reduces tumor growth in a C6 rat glioma model. Carmustine (0.5 mg/kg, i.p.) also reduces the number of amyloid-beta plaques and brain levels of amyloid-beta (1-40) (Abeta40), as well as increases brain levels of soluble amyloid precursor protein (sAPP) in the APP/PS1 transgenic mouse model of Alzheimer's disease. Formulations containing carmustine have been used in the treatment of gliomas and glioblastomas.Formal Name: N,N'-bis(2-chloroethyl)-N-nitroso-urea. CAS Number: 154-93-8. Synonyms: BCNU, bis-Chloroethylnitrosourea, NSC 409962. Molecular Formula: C5H9Cl2N3O2. Formula Weight: 214.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM, Water: 25 mM. lambdamax: 231 nm. SMILES: ClCCNC(N(N=O)CCCl)=O. InChi Code: InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11). InChi Key: DLGOEMSEDOSKAD-UHFFFAOYSA-N.